Establishment of a Humanized APL Model via the Transplantation of PML-RARA-Transduced Human Common Myeloid Progenitors into Immunodeficient Mice ... Genomic amplification of MYC as double minutes in a patient with APL-like leukemia.
275 Chromosome mapping of Miller-Diecker, Smith-Magenis and RARA loci in non-human primates: implications in the evolution of human ... Johansson, 1997. A breakpoint map research was financially supported by MURTS funds of recurrent chromosomal.
We explored these questions in the context of acute promyelocytic leukemia cells (NB4) expressing oncogenic fusion protein, PML–RARa and exquisitely sensitive to its clinically used antagonist, the all-trans retinoic acid (ATRA). We report that NB4 cells.
PML-RARA (Promyelocytic Leukemia) A group of several products for use with a range of rare forms of leukemia Ipsogen's tests are currently being used as a qualitative assay to diagnose various myeloproliferative diseases, a group of conditions that cause.
These include AML1-ETO (generated by t(8;21)), CBFB-MYH11 (generated by inv(16) or t(16;16)), PML-RARA (generated by t(15;17 ... This is done by mapping and cloning new chromosome translocation breakpoints and by analyzing the genomic structure of.
3,5,12 –20 However, to date, no attempts have been made to systematically characterize translocation breakpoints in APL cases that developed in this setting. In the present study, we analyzed at the genomic level the PML and RARA breakpoints of 14.
PML breakpoints cluster in two regions on either side of an alternatively spliced exon. Although leukemic cells with translocations characteristically express only one fusion product, both PML/RARA (on the 15q+ derivative chromosome) and RARA/PML (on the.
Introduction: Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation between chromosomes 15 and 17 yielding the PML-RARA fusion gene, which deregulates cell proliferation and blocks granulocyte differentiation. All-trans retinoic.
The translocation t(15;17) associated with acute promyelocytic leukemia results in the fusion of the retinoic acid receptor alpha (RARA) gene to the PML gene ... least three major transcription products. PML breakpoints cluster in two regions on either.
Because PML-RARA-induced acute promyelocytic leukemia (APL) is a morphologically differentiated leukemia, many groups have speculated about whether its leukemic cell of origin is a committed myeloid precursor (e.g. a promyelocyte) versus an hematopoietic.